Ketoprofen 50mg – 20 capsules
NSAIDs, a derivative of propionic acid. It has analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with inhibition of COX activity – the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.
The expressed analgesic effect of Ketoprofen is due to two mechanisms: peripheral (indirectly, through the suppression of prostaglandin synthesis) and Central (due to inhibition of prostaglandin synthesis in the Central and peripheral nervous system, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord). In addition, Ketoprofen has antibacterial activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Inhibits platelet aggregation.
When ingestion and rectal administration Ketoprofen is well absorbed from the gastrointestinal tract. Cmax in plasma by ingestion is achieved through 1-5 hours (depending on dosage form), rectal administration is 45-60 min, in/m introduction – after 20-30 min, on/in the introduction – 5 min.
Plasma protein binding is 99%. Due to the pronounced lipophilicity quickly penetrates through the BBB. Css in blood plasma and cerebrospinal fluid is stored from 2 to 18 h. Ketoprofen penetrates well into the synovial fluid, where its concentration after 4 h after administration exceeds that in plasma.
It is metabolized by binding to glucuronic acid and to a lesser extent by hydroxylation.
Excreted primarily by kidneys and to a much lesser extent through the intestines. T1/2 Ketoprofen from plasma after oral administration is 1.5-2 h, after rectal administration-about 2 h, after/m administration-1.27 h, after/in the introduction – 2 h.
Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout); symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system (shoulder, artrosinovit, tendonitis, tendosynovitis, bursitis, lumbago), pain in the spine, neuralgia, myalgia. Uncomplicated injuries, in particular sports, dislocations, stretching or rupture of ligaments and tendons, bruises, post-traumatic pain.
In combination therapy of inflammatory diseases of veins, lymphatic vessels, lymph nodes (phlebitis, periflebit, limphangit, superficial lymphadenitis).
Set individually depending on the clinical situation.
Contraindications to use
For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, severe liver and/or kidney function; III trimester of pregnancy; age up to 15 years (for retard tablets); hypersensitivity to Ketoprofen and salicylates.
For rectal use: proctitis and bleeding from the rectum in history.
For external use: wet dermatoses, eczema, infected abrasions, wounds.