Description

Loperamide 2mg – 20 tablets

Pharmacological action
Loperamide, communicating with opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of the smooth muscles of the intestine, slows down the passage of the contents of the intestine, reduces the release of fluid and electrolytes with feces. Increases the tone of the anal sphincter, helps to retain fecal masses and reduce the urge to defecate. Action comes quickly and lasts 4-6 hours.

Pharmacokinetics
Absorption-40%. The time required to achieve Cmax – 2.5 hours Connection with the plasma protein – 97%. T1/2 – 9-14 h does Not penetrate the blood-brain barrier. Almost completely metabolized in the liver by conjugation. It is excreted mainly by the intestine; a small part is excreted by the kidneys (in the form of conjugated metabolites).

Indications
Symptomatic treatment of acute and chronic diarrhoea of various etiology (allergic, emotional, drug, radiation: when changing power mode and qualitative composition of food in violation of metabolism and absorption: as adjuvant in diarrhoea of infectious origin). Regulation of stool in patients with ileostomy.

Dosage regimen
Inside, without chewing, drinking water.

Adults with acute and chronic diarrhea are initially prescribed 2 capsules (0.004 g), then 1 capsule (0.002 g) after each act of defecation in the case of liquid stool. In acute diarrhea, children over 6 years are prescribed 1 capsule (0.002 g) after each act of defecation in the case of liquid stool.

Maximum daily dose. In acute and chronic diarrhea in adults – 8 capsules (0.016 g); in children – 3 capsules (0.006 g).

After normalization of the chair or in the absence of a chair for more than 12 hours, Loperamide treatment should be discontinued.

Side effect
Allergic reactions (skin rash), drowsiness or insomnia, dizziness, hypovolemia, electrolyte disorders; dryness of the oral mucosa, intestinal colic, gastralgia, abdominal pain or discomfort, nausea, vomiting, flatulence.

Rarely-urinary retention, rarely-intestinal obstruction.

Contraindications to use
Hypersensitivity to the drug, lactose intolerance, lactase deficiency or glucose-galactose malabsorption, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, diarrhea on the background of acute pseudomembranous enterocolitis, in the form of monotherapy — dysentery and other infections of the gastrointestinal tract; pregnancy (I trimester), lactation, loperamide capsules are not prescribed to children under 6 years.

With caution. Liver failure.