Terbinafine 250mg 30 tablets
Antifungal groups of allylamine. Acts by inhibition of squalene epoxidase in the fungal cell membrane. This leads to a deficiency of ergosterol and intracellular accumulation of squalene, which causes cell death of the pathogen.
It has a fungicidal effect on dermatophytes, mold and some dimorphic fungi, yeast and yeast-like fungi. On some kinds of yeast fungi can act fungistaticeski.
Active against pathogens of dermatomycosis (Trichophyton /including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum/, also Microsporum canis and Epidermophyton floccosum); yeast fungi of the genus Candida (mainly Candida albicans); pathogen of multi-colored lichen (lichen Malassezia furfur).
After oral administration is well absorbed from the gastrointestinal tract. Plasma protein binding-99%. Terbinafin diffuses through the dermal layer of the skin and accumulates in the lipophilic stratum corneum, secreted into the skin fat, resulting in high concentrations in the hair follicles, nails. During the first few weeks after starting terbinafin accumulates in the skin and nail plates in concentrations that provide a fungicidal effect. It is metabolized in the liver to form inactive metabolites. Excreted in the urine, mainly in the form of metabolites. T1/2 – 17 h
For oral administration: fungal skin infections caused by dermatophytes, dermatophytosis, athlete’s, microsporia, fungal nails (onychomycosis), candidiasis.
Inside adults-250 mg / day in 1 or 2 admission. The duration of treatment depends on the indications and severity of infection: skin lesions – 2-4 weeks., with the defeat of nails – from 6 weeks. up to 4 months or more. Children weighing more than 40 kg-250 mg / day, 20-40 kg-125 mg/day, up to 20 kg – 62.5 mg / day.
From the digestive system: nausea, anorexia, moderate abdominal pain, diarrhea, disorders or loss of taste, cholestasis, jaundice, hepatitis.
Allergic reactions: skin rash; rarely-arthralgia, myalgia, erythema multiforme, Stevens-Johnson syndrome.
From the hematopoietic system: neutropenia, thrombocytopenia.